sciencePeptideDosage

Bronchogen Peptide: 4 Residues, 3 Papers, 0 Human Trials

Bronchogen peptide is Ala-Asp-Glu-Leu. The counts that matter: 12 PubMed hits of which about 3 are the compound, 1 registry record which is a different product, and 0 human trials.

verifiedMedically reviewed byMichael Bre, MD
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MEDICAL DISCLAIMER: Educational research guidelines only. Lyophilized peptides are investigational chemical compounds and are NOT approved for human consumption, diagnosis, or therapy. Consult a licensed physician before any research application.

Bronchogen peptide is four amino acids long, Ala-Asp-Glu-Leu, from the same Russian bioregulator family as epithalon. Every other page on this site turns a vial and a volume into a concentration. This one has no vial arithmetic to do, because the numbers that decide the compound are counts rather than milligrams.

Three counts settle it: how many papers exist, how many of them are about this peptide, and how many human trials are registered. Each is smaller than it first appears.

Count one: twelve results, of which about three

A PubMed search on the name returns roughly 12 records. That figure gets repeated as though it described a literature.

Read the titles and most concern bronchogenic cysts and bronchogenic carcinoma: a neonatal cyst diagnosed by ultrasound in 1989, a laparoscopic extirpation in 2006, a carcinoma case in 1988. Unrelated conditions sharing a word stem. The count is a property of the search, not of the evidence.

YearWhat was examinedOrganismPMID
2011Effect on DNA thermostabilityIn vitro21240358
2015Bronchial epithelium, induced obstructive lung pathologyRat26468022
2017Anti-inflammatory and regenerative effect, same modelRat30199201

Three papers. The 2011 one is also the source for the sequence.

Count two: one registry record, which is a different product

ClinicalTrials.gov returns exactly 1 record for the name, and at a glance it reads like a human trial.

It is NCT00746759, “Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS IDE”, sponsored by Allegro Diagnostics. Three fields settle what it is. Study type: observational. Listed intervention: a diagnostic device, marked in the record as not used as an intervention. Purpose: finding gene expression signatures in smokers that flag lung cancer earlier than imaging.

Allegro used the name BronchoGen for a diagnostic test. The registry matched the string, not the substance.

Count three: zero human trials, and what that forecloses

So the count of registered human trials of this peptide is 0, and the count of published human results is also 0.

That forecloses the calculation this site normally performs. A concentration in mg/mL is exact arithmetic once you have a labelled mass and a volume, but it only means something if a quantity has been established somewhere. For this compound no quantity has been established in a person, so there is no figure for the arithmetic to land on. The rat work states amounts per kilogram of animal body weight in a defined induced model, and per-kilogram animal figures do not convert across species.

A fuller reference on the compound and how it is sold is available in this guide to the bronchogen peptide.

The two checks, in order

Both take under a minute and both apply to any compound in this category.

In a literature search, read titles rather than the result count. Word stems inflate counts for anything with a common medical root, and this compound is a clean example: about 75 percent of its apparent literature is a different disease.

In a registry search, read study type and lead sponsor before you read the NCT number. Observational plus a diagnostics company is not an interventional trial of a peptide, whatever the search result implied.

Frequently Asked Questions

How many human trials of bronchogen peptide are registered?expand_more

Zero. The single record returned by a search on the name is an observational lung cancer diagnostic study run by a diagnostics company, matched on the string rather than the compound.

Why does PubMed return about twelve results?expand_more

Because most of them are about bronchogenic cysts and bronchogenic carcinoma, unrelated conditions that share a word stem. Filtered to the peptide, the literature is roughly three papers.

What is the sequence?expand_more

Ala-Asp-Glu-Leu, four residues. The 2011 paper on DNA thermostability, PMID 21240358, is the source that states it.

Can a concentration be calculated for it?expand_more

The arithmetic works the same as for anything else: labelled mass divided by diluent volume. What is missing is a quantity to aim at, because none has been established in a person.

Is it approved anywhere?expand_more

No regulator has authorised it in any market. It is sold as a research chemical.

References & Citations

  1. [1]

    Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bulletin of Experimental Biology and Medicine, 2011.View source →

  2. [2]

    Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. Bulletin of Experimental Biology and Medicine, 2015.View source →

  3. [3]

    ClinicalTrials.gov NCT00746759. Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS IDE. Observational; lead sponsor Allegro Diagnostics.View source →